Desmosomes in disease: a guide for clinicians.
Identifieur interne : 000121 ( Main/Exploration ); précédent : 000120; suivant : 000122Desmosomes in disease: a guide for clinicians.
Auteurs : A. Celentano [Australie, Italie] ; N. Cirillo [Australie]Source :
- Oral diseases [ 1601-0825 ] ; 2017.
Descripteurs français
- KwdFr :
- Autoanticorps (sang), Desmogléine-1 (immunologie), Desmogléine-2 (immunologie), Desmosomes (génétique), Desmosomes (immunologie), Desmosomes (métabolisme), Humains (MeSH), Maladies de la bouche (diagnostic), Maladies de la bouche (étiologie), Maladies génétiques congénitales (complications), Pemphigus (complications), Pemphigus (diagnostic), Pemphigus (immunologie).
- MESH :
- diagnostic : Maladies de la bouche, Pemphigus.
- génétique : Desmosomes.
- immunologie : Desmogléine-1, Desmogléine-2, Desmosomes, Maladies génétiques congénitales, Pemphigus.
- métabolisme : Desmosomes.
- sang : Autoanticorps.
- étiologie : Maladies de la bouche.
- Humains.
English descriptors
- KwdEn :
- Autoantibodies (blood), Desmoglein 1 (immunology), Desmoglein 2 (immunology), Desmosomes (genetics), Desmosomes (immunology), Desmosomes (metabolism), Genetic Diseases, Inborn (complications), Humans (MeSH), Infections (complications), Mouth Diseases (diagnosis), Mouth Diseases (etiology), Pemphigus (complications), Pemphigus (diagnosis), Pemphigus (immunology).
- MESH :
- chemical , blood : Autoantibodies.
- chemical , immunology : Desmoglein 1, Desmoglein 2.
- complications : Genetic Diseases, Inborn, Infections, Pemphigus.
- diagnosis : Mouth Diseases, Pemphigus.
- etiology : Mouth Diseases.
- genetics : Desmosomes.
- immunology : Desmosomes, Pemphigus.
- metabolism : Desmosomes.
- Humans.
Abstract
The large number of diseases occurring when desmosome constituents are impaired provides striking evidence for the key role of desmosomes in maintaining tissue integrity. A detailed understanding of the molecular alterations causing desmosomal dysfunction has, in turn, underpinned the development of novel diagnostic tools. This has salient clinical implications for dentists and oral medicine practitioners because the majority of desmosomal diseases affect the oral cavity. In the present article, we review the autoimmune, infectious, genetic, and neoplastic diseases that target the desmosome, with particular emphasis on clinical manifestations, diagnostic pathways, and relevant laboratory investigations.
DOI: 10.1111/odi.12527
PubMed: 27329525
Affiliations:
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A detailed understanding of the molecular alterations causing desmosomal dysfunction has, in turn, underpinned the development of novel diagnostic tools. This has salient clinical implications for dentists and oral medicine practitioners because the majority of desmosomal diseases affect the oral cavity. In the present article, we review the autoimmune, infectious, genetic, and neoplastic diseases that target the desmosome, with particular emphasis on clinical manifestations, diagnostic pathways, and relevant laboratory investigations.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27329525</PMID><DateCompleted><Year>2017</Year><Month>10</Month><Day>11</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1601-0825</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Oral diseases</Title><ISOAbbreviation>Oral Dis</ISOAbbreviation></Journal><ArticleTitle>Desmosomes in disease: a guide for clinicians.</ArticleTitle><Pagination><MedlinePgn>157-167</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/odi.12527</ELocationID><Abstract><AbstractText>The large number of diseases occurring when desmosome constituents are impaired provides striking evidence for the key role of desmosomes in maintaining tissue integrity. A detailed understanding of the molecular alterations causing desmosomal dysfunction has, in turn, underpinned the development of novel diagnostic tools. This has salient clinical implications for dentists and oral medicine practitioners because the majority of desmosomal diseases affect the oral cavity. In the present article, we review the autoimmune, infectious, genetic, and neoplastic diseases that target the desmosome, with particular emphasis on clinical manifestations, diagnostic pathways, and relevant laboratory investigations.</AbstractText><CopyrightInformation>© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Celentano</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Melbourne Dental School and Oral Health CRC, University of Melbourne, Melbourne, Vic., Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cirillo</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Melbourne Dental School and Oral Health CRC, University of Melbourne, Melbourne, Vic., Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Oral Dis</MedlineTA><NlmUniqueID>9508565</NlmUniqueID><ISSNLinking>1354-523X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001323">Autoantibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051183">Desmoglein 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051301">Desmoglein 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001323" MajorTopicYN="N">Autoantibodies</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051183" MajorTopicYN="N">Desmoglein 1</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051301" MajorTopicYN="N">Desmoglein 2</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003896" MajorTopicYN="N">Desmosomes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030342" MajorTopicYN="N">Genetic Diseases, Inborn</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007239" MajorTopicYN="N">Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009059" MajorTopicYN="N">Mouth Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010392" MajorTopicYN="N">Pemphigus</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">blistering diseases</Keyword><Keyword MajorTopicYN="N">desmosome</Keyword><Keyword MajorTopicYN="N">pemphigus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>06</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>06</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27329525</ArticleId><ArticleId IdType="doi">10.1111/odi.12527</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Italie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Celentano, A" sort="Celentano, A" uniqKey="Celentano A" first="A" last="Celentano">A. Celentano</name></region><name sortKey="Cirillo, N" sort="Cirillo, N" uniqKey="Cirillo N" first="N" last="Cirillo">N. Cirillo</name></country><country name="Italie"><noRegion><name sortKey="Celentano, A" sort="Celentano, A" uniqKey="Celentano A" first="A" last="Celentano">A. Celentano</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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